Cryptococcal infection may cause a pneumonia-like illness, with shortness of breath, coughing and fever. Skin lesions may also occur. Another common form of cryptococcosis is central nervous system infection, such as meningoencephalitis. People with cryptococcal meningoencephalitis are usually immunocompromised. Symptoms may include fever, headache, or change in mental status.
Incubation times vary for infection due to Cryptococcus species. Symptoms from C. gattii infection are estimated to begin anywhere from 2-11 months after exposure. The incubation time for C. neoformans is not known.